Penile erectile dysfunction after brachial plexus root avulsion injury in rats

نویسندگان

  • Guo Fu
  • Bengang Qin
  • Li Jiang
  • Xijun Huang
  • Qinsen Lu
  • Dechun Zhang
  • Xiaolin Liu
  • Jiakai Zhu
  • Jianwen Zheng
  • Xuejia Li
  • Liqiang Gu
چکیده

Our previous studies have demonstrated that some male patients suffering from brachial plexus injury, particularly brachial plexus root avulsion, show erectile dysfunction to varying degrees. However, the underlying mechanism remains poorly understood. In this study, we evaluated the erectile function after establishing brachial plexus root avulsion models with or without spinal cord injury in rats. After these models were established, we administered apomorphine (via a subcutaneous injection in the neck) to observe changes in erectile function. Rats subjected to simple brachial plexus root avulsion or those subjected to brachial plexus root avulsion combined with spinal cord injury had significantly fewer erections than those subjected to the sham operation. Expression of neuronal nitric oxide synthase did not change in brachial plexus root avulsion rats. However, neuronal nitric oxide synthase expression was significantly decreased in brachial plexus root avulsion + spinal cord injury rats. These findings suggest that a decrease in neuronal nitric oxide synthase expression in the penis may play a role in erectile dysfunction caused by the combination of brachial plexus root avulsion and spinal cord injury.

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عنوان ژورنال:

دوره 9  شماره 

صفحات  -

تاریخ انتشار 2014